The Scientist : Key to 'wasting syndrome' [10/12/2001]

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20011210-02

10 December 2001

A reduction in albumin production can cause of cachexia in patients with cancer or chronic inflammatory conditions, but the mechanism behind this inhibition remains unknown. In December 3 European Molecular Biology Organization Journal, Martina Buck and colleagues from VA San Diego Healthcare System and University of California, San Diego, show that tumor necrosis factor alpha (TNF-α) is the key molecule in the prevention of albumin production in chronic diseases.

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