The Scientist : Defective axonal transport in Alzheimer's disease [11/12/2001]

Defective axonal transport in Alzheimer's disease

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20011211-03

11 December 2001

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear. In December 6, Nature Adeela Kamal and colleagues from University of California, San Diego show that APP is involved in transport within nerve cells and shunts cellular materials along the axons.

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