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Telomere capping
Analysis of knockout mice has revealed a role for DNA-PK in mammalian telomere capping.
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2001, 2(1):20011213-01
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Telomeres protect the ends of chromosomes and prevent chromosomal end-to-end fusions. The DNA-dependent protein kinase (DNA-PK) has been implicated in DNA repair and telomere maintenance. In the December 18 Proceedings of the National Academy of Sciences, David Gilley and colleagues at the Lawrence Berkeley National Laboratory report the use of knockout mice to examine the function of the DNA-PK catalytic subunit (Proc Natl Acad Sci USA 2001, 98:15084-15088).
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