The Scientist : Genetic pathway to sudden death [19/12/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Genetic pathway to sudden death

A defect in KChIP2 is sufficient to confer a marked genetic susceptibility to ventricular tachycardia that would ordinarily lead to sudden death in humans.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20011219-02

Published

19 December 2001

KChIP2 (Kv Channel-Interacting Protein 2) is preferentially expressed in the adult heart and has a role in sustaining the normal rhythmic beating, but its role in cardiac pathology remains unclear. In December 14 Cell, Hai-Chien Kuo and colleagues from University of California, San Diego, La Jolla, USA, show that a defect in KChIP2 is sufficient to confer a marked genetic susceptibility to ventricular tachycardia that would ordinarily lead to sudden death in humans.

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