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RESEARCH ROUND-UP

Producing better antiviral peptide vaccines

Modification of natural viral proteins improves the quality as well as the quantity of immune responses.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20011219-03

19 December 2001

Natural viral proteins cannot constantly be used as optimal vaccines because they do not always stimulate efficiently the immune system. In December 1 Journal of Clinical Investigation, Jeffrey Ahlers and colleagues from National Institutes of Health, Bethesda, USA, show that sequence modification of natural viral proteins to increase epitope affinity for class II MHC molecules (epitope enhancement) can improve immunogenicity.


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