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Death domains, dysplasia and development
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2001, 2(1):20011220-01
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Edar is a member of the tumour-necrosis factor receptor (TNFR) family of signalling molecules that contains an intracellular death-domain. Mutation of the mammalian downless gene encoding Edar, or Tabby which encodes its ligand Eda, results in ectodermal dysplasia and defective morphogenesis. In the December 20/27 Nature, Headon et al. report characterization of the protein encoded by the mouse crinkled locus, a mutation in which results in hypohidrotic dysplasia identical to Tabby and downless mutants (Nature 2001, 414:913-916).
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