The Scientist : A surprising substitution [4/1/2002]

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020104-02

4 January 2002

Jun and JunB are components of a transcription factor (AP-1) involved in cell development and apoptosis, but their functional equivalence in vivo is unknown. In 2 January online Nature Genetics, Emmanuelle Passegué and colleagues from Research Institute of Molecular Pathology, Vienna, Austria, show that JunB — although transcriptionally less active than Jun — has the potential to substitute functionally for Jun.

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