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p53 controls ageing
Mice overexpressing p53 are resistant to tumor development but exhibit early onset of ageing.
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020107-03
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The p53 protein works to suppress cancer cells by the induction of senescence, apoptosis and cell cycle arrest, but its role in the longevity of organisms remains unknown. In 3 January Nature, Stuart Tyner and colleagues from Baylor College of Medicine, Houston, USA, show that p53 has a role in controlling ageing in mice.
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