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In silico chromosome staining
A computation method can re-create the chromosomal banding patterns characteristic of Giemsa staining.
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2002, 3(1):20020121-01
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The chromosomal bands observed upon Giemsa staining are thought to correspond generally to regions that are GC-poor (Giemsa-dark, G bands) and GC-rich (Giemsa-light, R bands). But, the exact relationship between sequence base composition and cytogentic banding is remains unclear. In the January 22 Proceedings of the National Academy of Sciences, Niimura and Gojobori describe a computational method to explore the association between the Giemsa banding pattern and local GC content (Proc Natl Acad Sci USA 2002, 99:797-802).
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