The Scientist : Fertile ground for gene therapy [1/2/2002]

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by Tudor Toma

RESEARCH ROUND-UP

Fertile ground for gene therapy

Adenovirus-mediated gene delivery into Sertoli cells of infertile mice can restore production of fertile spermatozoa.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020201-03

Published

1 February 2002

Sertoli cells are essential for spermatogenesis because of their interactions with germ cells, and a defect in their function can lead to the absence of spermatozoa (azoospermia) and male infertility. In January 29 online Proceedings of the National Academy of Sciences, Mito Kanatsu-Shinohara and colleagues from Graduate School of Medicine, Kyoto University, Kyoto, Japan, show that adenovirus-mediated gene delivery into Sertoli cells of infertile mice could successfully restore production of fertile spermatozoa.

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