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Mammalian gene 'knock-down'
Long double-stranded RNA can drive stable gene silencing in mammalian embryonic cell lines.
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2002, 3(1):20020206-01
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The use of RNAi (also known as double-stranded RNA-dependent post-transcriptional gene silencing) is revolutionizing genetic analysis in cellular systems. In the February 5 Proceedings of the National Academy of Sciences, Patrick Paddison and colleagues at the Cold Spring Harbor Laboratory describe a technique using long double-stranded RNA (dsRNA), of around 500 nt, to 'knock-down' gene expression in mammalian cell lines (Proc Natl Acad Sci USA 2002, 99:1443-1448).
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