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Insulin mimetics foil obesity
Activating central and peripheral insulin signaling with small molecule insulin mimetics reduces food intake and prevents obesity.
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020206-02
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Obesity is on the increase in industrialized countries and is a serious risk factor for diabetes and cardiovascular disorders, but effective pharmaceutical treatments for obesity remain elusive. In February Nature Medicine, Ellen Air and colleagues from University of Cincinnati College of Medicine, Cincinnati, Ohio, show that small molecule insulin mimetics can reduce food intake and body weight and prevent development of obesity in an animal model.
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