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'Off-switch' for systemic inflammation
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020211-02
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Systemic inflammation helps protects the body until a more specific immune response can be mounted. This process is mediated by several cytokines that act on the liver, but the molecular mechanisms controlling it remain unclear. In February 8 Cell, Joo-Yeon Yoo and colleagues, from Howard Hughes Medical Institute, Baltimore, USA, show that Stat3-β — a transcription factor activated in the liver by the IL-6 family of cytokines — has a critical role in the control of systemic inflammation.
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