Gonococcal immune suppression :The Scientist [18/2/2002]

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RESEARCH ROUND-UP

Gonococcal immune suppression

Neisseria gonorrhoea arrests the activation and proliferation of CD4+ T lymphocytes.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020218-02

18 February 2002

Patients infected with Neisseria gonorrhoea present with intense inflammation resulting in urethral or cervical pus discharge, but the specific immune response to the bacteria is weak and does not protect against subsequent gonococcal infections. In February 19 online Nature Immunology, Ian Boulton and Scott Gray-Owen from University of Toronto, Canada, show that N. gonorrhoea have a mechanism that can arrest the activation and proliferation of CD4⁺ T lymphocytes via the CEACAM1 adhesion molecules.


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