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Protease inhibitors kill tumors
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020305-02
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Patients infected with HIV-1 undergoing protease inhibitor (PI) treatment have a reduced incidence or regression of Kaposi sarcoma (KS), but the molecular mechanism of this response remains unclear. In March Nature Medicine, Cecilia Sgadari and colleagues from Istituto Superiore di Sanità, Rome, Italy, show that HIV protease inhibitors promote regression of KS because they are potent anti-angiogenic molecules.
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