The Scientist : PRIMA facie evidence [6/3/2002]

Supplements

Survey Series

The Scientist Daily

Science headlines delivered daily.
Register today.

For Advertisers

by Tudor Toma

RESEARCH ROUND-UP

PRIMA facie evidence

A small molecule, called PRIMA-1, can restore the tumor suppressor function of p53 in human tumor cells.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020306-02

Published

6 March 2002

The tumor suppressor p53 triggers cell-cycle arrest and apoptosis but about 50% of human tumors have mutations in p53 which makes them resistant to apoptosis. Vladimir Bykov and colleagues from Karolinska Institutet, Stockholm, Sweden hypothesized that restoring p53 in tumor cells could trigger massive apoptosis and eliminate the tumor. In March Nature Medicine, they show that a small molecule, called PRIMA-1, can restore the tumor suppressor function of p53 and have anti-tumor effects.

Password

> Forgot Password?
> FAQ
> Subscribe

Subscribing to The Scientist is easy and inexpensive.

And you can choose from many options. Try us out with an online day pass starting at only $4.95. Or, get it all with unlimited online access to The Scientist Archive and door-to-door delivery of our monthly print magazine.


	The Scientist also offers site licenses to institutions and organizations. When your librarian adds The Scientist to the library's collection, you can get unlimited online access through your place of work or study. Recommend The Scientist today