The Scientist : Shotgun strategies [7/3/2002]

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by Jonathan B Weitzman

RESEARCH ROUND-UP

Shotgun strategies

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2002, 3(1):20020307-01

Published

7 March 2002

The two groups that published the draft sequence of the human genome last year used different experimental strategies. The public Human Genome Project used a hierarchical shotgun (HS) approach, whereas Celera Genomics chose a whole-genome shotgun (WGS) strategy. In the Early Edition of the Proceedings of the National Academy of Sciences, three leaders of the Human Genome Project question the validity of Celera's claim to have generated their draft sequence by WGS (Proc Natl Acad Sci USA 2002, 10.1073/pnas.042692499).

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