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Overcoming immune ignorance
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020313-02
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Enhancing T cell responses with specific mAbs can mediate the regression of selected murine tumors, but several cancers remain resistant to such treatments. In March 1 Journal of Clinical Investigation, Ryan Wilcox and colleagues from Mayo Clinic, Rochester, Minnesota, show that provision of CD137 (a T cell-borne relative of the TNF receptor) signaling associated with an anti-CD13 mAb breaks immunological ignorance and promotes regression of poorly immunogenic tumors.
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