Anti-malarial mechanism unraveled - The Scientist

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by Tudor Toma

RESEARCH ROUND-UP

Anti-malarial mechanism unraveled

Differences in the regulation of dihydrofolate reductase-thymidylate synthase may explain antifolate efficacy against Plasmodium falciparum.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020423-02

Published

23 April 2002

For more than 50 years antifolate drug therapy has been used successfully to treat malaria caused by Plasmodium falciparum. It had been assumed that differences between host and parasite in terms of the drug binding to dihydrofolate reductase-thymidylate synthase (DHFR-TS) were responsible for this success. But, in 19 April Science, Kai Zhang and Pradipsinh Rathod of University of Washington, Seattle, show that it may be differences in the regulation of DHFR between host and parasite that explain the efficacy of antifolate against P. falciparum (Science 2002, 296:545-547).


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