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Insulin galore
Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature intestinal stem cells to differentiate into insulin-producing cells.
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020507-03
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Type I diabetes is caused by the destruction of insulin secreting cells and consequently treatments focus on either replacing or regenerating insulin production. In May Diabetes, Hideto Kojima and colleagues from Shiga University of Medical Science, Japan show that combined expression of pancreatic duodenal homeobox 1 (Pdx-1) and islet factor 1 (Isl-1) can cause immature intestinal stem cells to differentiate into insulin-producing cells (Diabetes 2002, 51:1398-1408).
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