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The weak point of PEO
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020508-02
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Progressive external ophthalmoplegia (PEO) is an autosomal mitochondrial disorder associated with depletion of the mitochondrial genome and/or the accumulation of mutations and deletions within mtDNA. In May 3 Journal of Biological Chemistry, Mikhail Ponamarev and colleagues from National Institutes of Health, North Carolina, show that a point mutation in the mitochondrial DNA polymerase γ (pol γ) causes error-prone DNA synthesis in PEO (J Biol Chem 2002, 277:15225-15228).
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