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Finding the needle in the haystack
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020514-02
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Current techniques for identifying novel antibiotics are based on broad cell-based screenings of antibacterial molecules, but these methods do not reveal the biochemical target of a lead compound. In May Nature Biotechnology, Joseph DeVito and colleagues from Bristol-Myers Squibb Company describe a new array of target-specific screening strains of Escherichia coli that can identify antibiotic compounds with good inhibitory activity against more than one essential target (Nat Biotechnol 2002, 20:478-483).
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