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Oncogenic phosphatase amplification
Amplification of a genomic locus encoding a phosphatase modulates tumor suppression.
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2002, 3(1):20020527-01
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Post-translational regulation of p53 regulates its activity and tumor suppressor functions. In an Advanced Online Publication in Nature Genetics, Dmitry Bulavin and colleagues from the National Institutes of Health describe how oncogenic Ras regulates p53 phosphorylation (Nat Genet 2002, DOI:10.1038/ng894).
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