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Somatic hypermutation
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2002, 3(1):20020618-01
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Somatic hypermutation, gene conversion and class-switch recombination are genetic rearrangements that generate the molecular diversity of immunoglobulin genes underlying the human immune system. In the 14 June Science, Kiyotsugu Yoshikawa and colleagues report that a single enzyme, activation-induced cytidine deaminase (AID), is sufficient to generate somatic hypermutation in fibroblasts cells (Science 2002, 296:2033-2036).
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