The Scientist : IL-13 mediates asthma [1/7/2002]

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by Tudor Toma

RESEARCH ROUND-UP

IL-13 mediates asthma

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020701-04

Published

1 July 2002

Asthma is characterised by airway hyperreactivity (AHR), mucus overproduction and chronic eosinophilic inflammation mediated by Th2 lymphocytes, but no single molecule has been identified that could be pivotal to the mechanism of the disease. In 1 July advanced online Nature Medicine, Douglas Kuperman and colleagues at University of California San Francisco, School of Medicine show that direct effects of interleukin-13 on epithelial cells causes AHR and mucus overproduction in asthma.

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