The Scientist : Antibody based toothpaste [2/7/2002]

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by Tudor Toma

RESEARCH ROUND-UP

Antibody based toothpaste

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020702-02

Published

2 July 2002

Antibody fragments can prevent colonization of teeth by Streptococcus mutans — a major pathogen implicated in the development of dental caries — but these fragments have a very short half-life in vivo. In July Nature Biotechnology, Carina Krüger and colleagues at Karolinska Institutet at Huddinge Hospital, Sweden, show that lactobacilli producing single-chain antibodies can be used for in situ therapeutic delivery of passive immunity at oral mucosal sites (Nat Biotechnol 2002, 20:702-706).

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