The Scientist : defect in Huntington's disease [2/7/2002]

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by Tudor Toma

RESEARCH ROUND-UP

Mitochondrial Ca²⁺ defect in Huntington's disease

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020702-03

Published

2 July 2002

Huntington's disease (HD) is neurodegenerative illness caused by CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the precise molecular mechanisms involved in the pathogenesis of the disease have remained unclear. In 1 July advanced online Nature Neuroscience, Alexander Panov and colleagues at Emory University School of Medicine, Atlanta, US, show that mutant Htt have a direct effect on mitochondria and cause mitochondrial calcium handling defects (Nat Neurosci 2002, DOI: 10.1038/nn884).

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