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Redox controls HIV entry
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020703-02
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CD4 mediates immune cell-cell interactions and is required for HIV to enter cells, but the precise nature of the molecular interactions involved has been unclear. In July 1 advanced online Nature Immunology, Lisa Matthias and colleagues at the University of New South Wales, Sydney, Australia, show that disulfide exchange in domain 2 of CD4 is required for entry of HIV-1 into susceptible cells (Nat Immunol 2002, DOI: 10.1038/ni815).
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