The Scientist : Myeloperoxidase controls NO and vascular tone [4/7/2002]

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by Tudor Toma

RESEARCH ROUND-UP

Myeloperoxidase controls NO and vascular tone

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020704-03

Published

4 July 2002

Myeloperoxidase (MPO) is an abundant phagocyte hemoprotein with well-established microbicidal functions in vitro, but its role in blood infections has been unclear. In 28 June Science, Jason Eiserich and colleagues from University of California, Davis, USA, show that leukocyte-derived myeloperoxidase is a vascular NO oxidase that can directly modulate vascular inflammatory responses by regulating NO bioavailability (Science 2002, 296:2391-2394).

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