The Scientist : Getting rid of nonsense [5/7/2002]

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2002, 3(1):20020705-01

5 July 2002

Many human diseases are caused by point mutations that affect RNA splicing. It has been observed that nonsense mutations that generate premature termination of translation products can drive the use of alternative splicing to rescue protein function. In the July 5 Science, Jun Wang and colleagues describe the affects of nonsense mutations on splicing of the T-cell receptor-β (TCRβ) gene (Science 2002, 297:108-110).

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