The Scientist : Methylcytosine and mutation [22/7/2002]

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2002, 3(1):20020722-01

22 July 2002

MBD4 is a methyl-CpG-binding protein with thymine-DNA glycolase-activity that can remove T bases from T-G mismatches within a CpG context. In the 19 July Science, Catherine Millar and colleagues describe analysis of mice lacking the Mbd4 gene (Science 2002, 297:403-405).

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