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The real culprit in Graves disease
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020724-01
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In Graves disease, thyroid-stimulating autoantibodies activate the thyrotropin receptor (TSHR), leading to increased thyroid hormone secretion and clinical thyrotoxicosis, but the exact molecular interactions are not know. In 15 July Journal of Clinical Investigation, Gregorio D. Chazenbalk and colleagues show that the thyroid-stimulating autoantibodies preferentially recognize the free A subunit, not the thyrotropin holoreceptor (J Clin Invest 2002, 110:209-217).
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