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A new limb formation model
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020802-03
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Limb formation is currently explained by a long-standing model, which states that signals from tissue in the limb bud called the apical ectodermal ridge (AER) instruct cells of the upper arm to form first, followed by cells of the forearm, and finally cells of the hand. But two papers in August 1 Nature challenge this view and present evidence that all cell types are produced at the same time in the limb bud, and then, under the control of the AER, the different regions of cells expand at different times to form the complete limb.
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