The Scientist : tricks [5/8/2002]

Email: Jonathan Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2002, 3(1):20020805-01

5 August 2002

X-chromosome inactivation (XCI) is controlled by expression of the Tsix gene and its regulation of Xist mRNA accumulation. Deleting one copy of Tsix results in skewed XCI towards the mutated X chromosome in female soma. In an Advanced Online Publication in Nature Genetics Jeannie Lee reports the generation of homozygous Tsix-null mice by breeding heterozygote animals (Nat Genet 2002, DOI:10.1038/ng939).

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