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Cytomegaloviruses nuclear drill
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2002, 3(1):20020806-02
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The capsids of herpesvirus are too large to pass through the nuclear pore complex. That they are seen in the nucleus suggests that they are able to penetrate the nuclear membrane, but the precise mechanism they employ has remained unclear. In August 2 Science Walter Muranyi and colleagues from Ludwig-Maximilians-Universität München, Germany, show that cytomegaloviruses recruit cellular kinases to dissolve the nuclear lamina and penetrate the nuclear envelope (Science 2002, 297:854-857).
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