The Scientist : Leukemia in Down syndrome X-linked [12/8/2002]

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020812-04

12 August 2002

Children with Down syndrome have a high risk of developing acute megakaryoblastic leukemia (AMKL) but the genetic mechanisms involved have remained elusive. In August 12 advanced online Nature Genetics, Joshua Wechsler and colleagues at the University of Chicago, Illinois, US, show that loss of the full length GATA1 constitutes one step in the pathogenesis of AMKL in Down syndrome (Nat Genet 2002, DOI:10.1038/ng955).

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