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Small detail makes big difference
News from The Scientist 2002, 3(1):20020819-02
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The glycosyltransferase enzymes GTA and GTB produce the A and B antigens on human erythrocytes, but the precise biochemistry involved in the specific interaction with substrate molecules has been unclear. In August 19 Nature Structural Biology, Sonia Patenaude and colleagues at the University of Ottawa, Canada, describe the structural basis for distinct ABO(H) blood group biosynthesis in humans (Nat Struct Biol 2002, DOI:10.1038/nsb832).
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