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Mutant candidate for TB vaccine
News from The Scientist 2002, 3(1):20020909-03
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HIV and the emergence of drug resistant mycobacteria have once again elevated tuberculosis to disease of worldwide importance but, with the possible exception of bacille Calmette-Guerin (BCG), there is currently no vaccine against this disease. In September 9 Nature Medicine, Vasan Sambandamurthy and colleagues at the Albert Einstein College of Medicine, New York, describe a pantothenate auxotroph of Mycobacterium tuberculosis that is highly attenuated and protects mice against tuberculosis (Nat Med 2002, DOI:10.1038/nm765).
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