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Some like it hot
News from The Scientist 2002, 3(1):20020912-02
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In the food-borne pathogen Listeria monocytogenes, virulence genes are expressed at 37°C, but not 30°C. This process is under the control of PrfA — a transcriptional activator thermoregulated by a mechanism that has remained unclear. In September 6 Cell, Jörgen Johansson and colleagues from Institut Pasteur, Paris, show that an untranslated mRNA (UTR) preceding prfA acts as a thermosensor and controls Listeria monocytogenes expression of virulence genes at 37°C (Cell 2002, 110:551–561).
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