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Tryptophan controls tolerance
News from The Scientist 2002, 3(1):20020930-01
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The cytotoxic T lymphocyte–associated antigen 4–Ig prolongs allograft survival in several rodent models and in some instances can lead to tolerance induction, but the exact mechanisms involved have been unclear. In September 30 Nature Immunology, Ursula Grohmann and colleagues at the University of Perugia, Italy, show that CTLA-4–Ig modulates tryptophan catabolism and acts as a ligand for B7 receptor molecules that transduce intracellular signals (Nature Immunology, DOI:10.1038/ni846, September 30, 2002).
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