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MCP-1 important in HIV
News from The Scientist 2002, 3(1):20021002-01
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The monocyte chemoattractant protein-1 is a potent cell signaling molecule involved in the activation of mononuclear phagocytes, but its role in the pathogenesis of HIV-associated dementia (HAD) has been unclear. In the September 30 early edition of Proceedings of the National Academy of Sciences, Enrique Gonzalez and colleagues at the University of Texas Health Science Center, San Antonio, US show that a mutant MCP-1 allele influences susceptibility to HIV-1 infection and AIDS dementia (PNAS, DOI/10.1073/pnas.202357499, September 30, 2002).
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