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Cutting kinase calms mice
News from The Scientist 2002, 3(1):20021008-01
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Severe and excessive anxiety is associated with irregular levels of neurotransmitters in the brain but the precise biochemical mechanisms involved have been incompletely understood. In October 1 Journal of Clinical Investigation Clyde Hodge and colleagues at the Ernest Gallo Clinic and Research Center at the University of California, San Francisco, USA, show that absence of protein kinase Cε in mice reduces anxiety-like behavior and stress responses by enhancing gamma aminobutyric acid (GABAA) receptor function in the brain (Journal of Clinical Investigation, 110:1003-1010, October 1, 2002).
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