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New hope for Alzheimer's vaccine
News from The Scientist 2002, 3(1):20021014-02
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Immunization using amyloid-β peptide (Aβ) reduces both the Alzheimer's–like neuropathology and spatial memory impairments in animal models. But in humans these treatments have been associated with complications such as meningo-encephalitic cellular inflammatory reactions in some patients. Two papers in October 15 Nature Medicine, show that vaccines designed to clear amyloid-beta (Aβ) protein in Alzheimer's patients are selective for the pathogenic target structures and can be further refined to become more selective.
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