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Langerhans life cycle
News from The Scientist 2002, 3(1):20021106-04
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Langerhans cells are bone marrow–derived epidermal dendritic cells that represent the principal hematopoietic barrier to the external environment, but little has been known about their life cycle. In November 4 Nature Immunology, Miriam Merad and colleagues at Stanford University School of Medicine, Stanford, USA show that LCs renew in the skin throughout life under steady-state conditions and are replaced by blood-borne progenitors only after severe inflammatory changes (Nature Immunology, doi:10.1038/ni852, November 4, 2002).
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