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The need for Nbs1
Email: Jonathan Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2002, 3(1):20021107-01
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Eukaryotic cells have developed two independent pathways to repair double-strand breaks in their DNA: non-homologous end-joining (NHEJ) and homologous recombination (HR). A complex containing Mre11, Rad50 and Nbs1 proteins has been implicated in double strand break repair, but its exact function is unclear. In the November 7 Nature, Hiroshi Tauchi and colleagues characterized the role of the Mre11-Rad50-Nbs1 complex in vertebrate cells by creating Nbs1 knockout cells (Nature 2002, 420:93-98).
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