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HLA route infection fate
News from The Scientist 2002, 3(1):20021118-03
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Infection with group A streptococci (GAS; Streptococcus pyogenes) causes a wide spectrum of disease ranging from pharyngitis to streptococcal toxic shock syndrome, but the molecular mechanisms that control this range of responses has been unclear. In November 18 Nature Medicine, Malak Kotb and colleagues at the University of Tennessee, Memphis, USA, show that human leukocyte antigen class II allelic variation contributes to differences in the severity of invasive streptococcal infections through their ability to regulate cytokine responses triggered by streptococcal superantigens (Nature Medicine, doi:10.1038/nm800, November 18, 2002).
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