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Astrocytes tell vessels when to dilate
News from The Scientist 2002, 3(1):20021125-02 doi:10.1186/20021125-02
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The brain increases blood flow to specific areas when neurons are in a highly activated state – an event known as functional hyperaemia. This process is fundamental to brain function, but the signaling pathways involved have been poorly understood. In November 25 Nature Neuroscience, Micaela Zonta and colleagues from Università di Padova, Italy, show that neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation (Nature Neuroscience, doi:10.1038/nn980, November 25, 2002).
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