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Leishmania's favorite T cells
News from The Scientist 2002, 3(1):20021205-01 doi:10.1186/20021205-01
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Leishmania major is a tropical protozoan parasite transmitted to mammalian hosts by its sand fly vector. The parasite can persist in its host, but how the pathogen is able to establish this latency remains unclear. In December 5 Nature, Yasmine Belkaid and colleagues at the National Institutes of Health, Bethesda, USA, show that dermal L. major persistence after healing is controlled by an endogenous population of CD4+ CD25+ regulatory T cells (Nature, 420:502-507, December 5, 2002).
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