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Inward route for malaria
News from The Scientist 2002, 3(1):20021209-03 doi:10.1186/20021209-03
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A deletion in the glycophorin C gene (GYPC ∆ex3) results in a negative Gerbich (Ge) blood group common in Papua New Guinea where malaria is hyperendemic. Ge negativity is correlated to reduced susceptibility to malaria infection, but how this protection arises has been unclear. In December 9 Nature Medicine, Alexander G. Maier and colleagues at The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, show that GYPC mediates a principal Plasmodium falciparum invasion pathway into human erythrocytes (Nature Medicine doi:10.1038/nm807, December 9, 2002).
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