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HIV gene therapy
News from The Scientist 2002, 3(1):20021231-05 doi:10.1186/20021231-05
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Small interfering RNA (siRNA) can reduce the expression of specific cellular genes and inhibit viral replication, but their use against viral infections has been limited by the lack of an effective method for introducing siRNAs into primary cells. In the January 7 Proceedings of the National Academy of Sciences, Xiao-Feng Qin and colleagues at the California Institute of Technology, Pasadena, USA, show that lentiviral-mediated delivery of small interfering RNA against CCR5 can inhibit HIV-1 infection in human T cells (PNAS, 100:183-188, January 7, 2003).
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